Day 2 :
Medical University of Vienna, Austria
Keynote: Accumulation of highly stable ΔFosB-isoforms and its targets inside the reward system of chronic drug abusers – A source of dependence memory and high relapse rate?
Time : 09:30-10:10
Monika H. Seltenhammer completed her VMD. and Ph.D. from VMU in Austria and postdoctoral studies from Veterinary University of Vienna, Max Perutz Laboratories and Medical University of Vienna in Austria, where her core area of scientific work mainly consisted in cancer research (melanoma) and pathology, but also immunology, neurology and virology. Dr. Monika H. Seltenhammer has received several honor and awards. She is a leading member of the scientific staff of Dr. Daniele Ugo Risser at the Department of Forensic Medicine of the Medical University Vienna, where she specializes in neurobiology and addiction behavior
Background: The ~33kD transcription factor DFosB, a Fos-family protein, belonging to the immediate early genes (IEGs), is initiated in the acute phase as a response to a wide range of effects such as drugs, stress, and several external stimuli. DFosB forms heterodimers with Jun proteins to generate active activator-protein-1 (AP-1)-complexes. Currently, several downstream target genes for DFosB have been identified being involved in molecular pathways concerning addictive behavior, memory and learning. In answer to chronic stimuli, the rather unstable ~33kD transcription factor DFosB is replaced by robust ~35-37 kD isoforms due to epigenetic splicing and phosphorylation steps. These highly stable isoforms accumulate in the nucleus accumbens (NAc), a structure close to the hippocampus (HPC), playing a key role within the reward center of the brain. The stabilized ~35-37 kD DFosB derivatives linger in the brain for very long time; even beyond cessation of the chronic stimulus. A fact that seems to be responsible for the development of sustained neuronal plasticity, (drug-associated) long-term potentiation (LTP) and memory, and finally high relapse rates.
Method: DFosB and cAMP response element binding protein (CREB), brain derived neurotrophic factor (BDNF), JunD, nuclear factor kappa B (NFkB), and cyclin-dependent kinase 5 (Cdk5) in both of the NAc and HPC of deceased chronic human opioid addicts were proven by immunohistochemistry. Immunoblots were positive for accumulated ~35-37 kD DFosB isoforms.
Results: All determined proteins showed a significant increased staining pattern in brain samples of chronic drug abusers in comparison non-drug users (p<0.05) according to Wilcoxon-Mann-Whitney-U Test. Further, accumulated ~35-37 kD DFosB isoforms were detectable in NAc samples of long-term drug addicts by immunoblotting in contrast to the control group, where no trace of any isoform was verifiable (p<0.05) according to Wilcoxon-Mann-Whitney-U Test.
Conclusion: Our findings provide additional evidence of the potential strong impact of DFosB on its downstream transcriptional targets, which are in turn responsible for sustainable effects and serious adaptations in the brain leading to addictive behavior and dependence memory.
Softech Institute, Poland
Time : 10:10-10:50
Shranick Sethia holds a postgraduate degree in software engineering and has 13 years of experience as successful IT Entrepreneur. He combines a profound technical knowledge and experience with a strong sense of the requirements of the industry. As a teenager he was already working as a software developer, out of a fascination for IT. He have worked on many enterprise solutions for medical industry. Worked closely with doctors and professors in developing solutions
Mixed Reality is the merging of real and virtual worlds to produce new environments and visualizations where physical and digital objects co-exist and interact in real time.
Mixed reality takes place not only in the physical world or the virtual world, but is a mix of reality and virtual reality, encompassing both augmented reality and augmented virtual reality.
Students of all ages attempt to understand the beautiful complexity of the human body, a quite tedious and daunting task. In today’s classroom, students learn anatomy primarily through images and the written word. These formats do not completely capture the complexities of human anatomy as they represent 3D material in a flat two dimensional image. To improve student understanding and to accelerate learning across all age groups, innovations need to be made in the teaching of anatomy.
This is where our Platform steps in, we not only aim to provide 3D Content, Step by Step tutorials, Study Materials but also connect them to the Professors / Doctors or other Students in Real Time to ask questions/doubts or discuss any topic. Making a Virtual Classroom in Real World.
Real body for students and young Doctors to practice are becoming rare and of low quality due to the increased number of practice on the same body. We will offer an alternative to learning and practicing on real body, available for students and young Doctors.
MCorpus 3D and MR platform will advantageously replace the real body for surgeon and anatomy learning and practice. At the edge of the new technology, Mcorpus platform is outperforming any available solution currently on the market. Easy and intuitive to use, students and Doctors will be able to focus on the essence of learning and practicing with a single finger touch. The technology will place them in their usual environment and with they will be expected to practice the regular gestures
McMaster University, Canada
Keynote: Health digitization & the internet of things: Impact on next generation human health & well-being on a global scale
Time : 10:50-11:30
Joseph Tan formerly Wayne C Fox Chair of e-Business Innovation and currently, professor of eHealth Informatics, DeGroote School of Business, McMaster University, is the founding and ongoing editor-in-Chief, International Journal of Healthcare Information Systems & Informatics with a professional background that spans a broad spectrum of interdisciplinary and trans-disciplinary research area. A lead investigator in redefining the frontiers of multidisciplinary Business and Health IT knowledge development, management and expansion, including active involvement in collaborative research and multidisciplinary joint-grant submissions. He has demonstrated skills and ability to serve in both academia and industry. He has also achieved recognized scholarship in teaching and learning with students’ nominations for teaching excellence awards. His overall career focus is on reshaping the landscape of IS/IT applications and promotion in e-Health informatics through cross-disciplinary thinking/project partnering with diverse practitioners, clinicians, researchers, and a variety of user communities.
The last few decades have been marked with rapidly changing demographics, major destabilization of global economies, ongoing environmental disasters and other unpredictable events, such as the Fukushima accident, global climate change impacts, ongoing terrorist activities and warfare. These events emphasize a need for healthcare that is more cost-effective, affordable, timely, and most importantly, able to effectively coordinate efforts among different nations, disciplines and organizations. Traditionally, health service providers and healthcare workers are often regarded as key guardians of the health and well-being of global citizens, yet a need for community-relevant, self-administered healthcare services is now overwhelming, for the insured as well as the “non-insured”. In an era of low-cost smart technologies and wireless communication capabilities, many countries will now be looking for a new generation of well-trained and engaged users of these new and innovative e-health technologies. These users will include bot the healthcare professionals and patients, as well as other end users in varying and unpredictable roles, such as community healthcare workers, family members, military and non-governmental organizations. These users, large in numbers and diverse in roles, will now require a certain level of knowledge and skills when working with these new e-health technologies, so that the possibility of delivering healthcare in an unstable context with large-scale effects. Referred to as e-health informatics competencies, they provide a significant advantage over wasteful, poorly coordinated and expensive conventional medical procedures, and hold the potential for leveling the playing fields in terms of delivering care where and when it may be most critically needed, especially for the underserved. Understanding the e-health informatics competency challenges and trends is therefore a critical step towards identifying the various roles that could or should be played to aid policymakers, vendors, and/or researchers in this age of the Internet of Things.